Dear Student
Vaccination may be defined as protection of the body from communicable diseases by the administration of some agents that mimic the microbe. The agent can be a suspension of killed or attenuated microbes, or a substance that mimics the disease-causing microbes.
Smallpox vaccine, the first successful vaccine to be developed, was introduced by Edward Jenner in 1798. He followed up his observation that milkmaids who had previously caught cowpox did not later catch smallpox by showing that inoculated cowpox protected against inoculated smallpox.
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