The liver plays a chief role in excretion. It converts the excessive amount of amino acids present in blood into ammonia and pyruvic acid in their oxidative deamination.
Pyruvic acid oxidizes to release energy while amino acids are converted into less harmful substances, the urea which is filtered from the blood by the kidney. This urea is then released with urine.
The liver also separates dead RCBs from the circulatory system and also converts its haemoglobin into useful bile salts. The liver also converts the cholesterol, skatol, and indole into less harmful substances and then mixes them in the circulatory system. Kidney filters these substances from the blood.