Question

You need to make a transgenic animal which will produce a protein that dissolves blood clots. Which of the following transgenes will you use?

• A. BRCA1
• B. Actin gene
• C. t-PA gene
• D. Cry gene

Answer 1

The correct option is C

t-PA gene

Transgenic mice have been engineered to produce a protein that dissolves thrombi or blood clots in heart attacks called t-PA or human tissue plasminogen activator. The human gene for t-PA was fused with the mouse promoter gene for acidic whey protein which isthe most common protein found in milk. Thus, the human t-PA protein was produced in the milk of the mouse and was easily obtained in high quantities.