Both nucleotide and nucleoside have pentose sugar and nitrogenous base. Nucleotide differs from nucleoside with the presence of phosphoric acid as nucleoside do not have phosphoric acid.
- They are building blocks of nucleic acid, as nucleotides consist of the same components such as a nitrogenous base, sugar and a phosphate group.
- The key difference is that nucleosides contain only sugar and a base, while nucleotides contain sugar, base, and a phosphate group.
- A nucleotide comes before RNA and DNA, and a nucleoside comes before the nucleotide itself.