In the eukaryotic cell cycle, chromosome duplication occurs during phase S, and chromosome division occurs during phase M.
. The content of DNA doubles for haploid cells and diploid cells.
Consequently, the formation of duplicate gene-sets occurs. In addition to the DNA replication, new chromatin fibres form which, however, stay intact in pairs.
The chromosome number does not increase.
During the S phase, any problems with the DNA replication trigger checkpoint- a cascade of signaling events that interrupt the phase until the problem is resolved.
The S phase works as a checkpoint surveillance camera.
Final answer: The chromosome replication occurs during the S phase.