What are checkpoints in cell cycle?

checkpoint is a stage in the eukaryotic cell cycle at which the cell examines internal and external cues and ‘decides’ whether to move forward with the division.

Three main checkpoints in the cell cycle:

A checkpoint is a stage in the eukaryotic cell cycle at which the cell examines internal and external cues and ‘decides’ whether to move forward with division.

There are a number of checkpoints, but the three most important ones are:

The G1 checkpoint, at the G1/S transition.

  • Size. Is the cell large enough to divide?
  • Nutrients. Does the cell have enough energy reserves or available nutrients to divide?
  • Molecular signals. Is the cell receiving positive cues (such as growth factors) from neighbours?
  • DNA integrity. Is any of the DNA damaged?

The G2 checkpoint, at the G2/M transition.

At this stage, the cell will check:

  • DNA integrity. Is any of the DNA damaged?
  • DNA replication. Was the DNA completely copied during the S phase?

The spindle checkpoint, at the transition from metaphase to anaphase.

Was this answer helpful?

 
   

1 (3)

(4)
(0)

Choose An Option That Best Describes Your Problem

Thank you. Your Feedback will Help us Serve you better.

Leave a Comment

Your Mobile number and Email id will not be published. Required fields are marked *

*

*

BOOK

Free Class

Ask
Question