What is the proper sequence in mitosis?

There are two main events in mitosis – karyokinesis or duplication of the nucleus, followed by cytokinesis or division of the cytoplasm. The separation of the daughter cells follows this. Thus, Karyokinesis is divided into four stages – prophase, metaphase, anaphase and telophase.

  • Prophase – During prophase, chromosomes get visible (chromatids), the centrioles migrate to the poles, nuclear membrane and nucleolus disappear, and spindle formation is seen. Prophase in mitosis is longer than any other mitosis phase because the cell has to prepare for the actual division that takes place from early through late prophase.
  • Metaphase – During this, chromosomes line up around the centre (Cells in metaphase have the chromosomes, which appear as long thin strands under the microscope).
  • Anaphase – here, chromatids separate and move to opposite poles by spindle fibres. This allows each daughter cell to have an identical copy of each of the original cell’s chromosomes.
  • Telophase – During this phase, chromosomes disappear (become chromatin), nuclear membrane reforms, nucleoli reappears, spindle disappears, and centrioles duplicate.

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