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Question

How do histones work?


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Solution

Histones:

  1. Histones help in packaging DNA into chromatin so that it can fit in the nucleus.
  2. It provides structural support to chromosomes.
  3. DNA gets wrapped around the histone octamer.
  4. Histones are basic proteins found in chromosomes.
  5. They help in the packing and organization of DNA helix in chromatin fiber in the nucleus.
  6. They also regulate gene expression.
  7. In eukaryotes, DNA is highly condensed and is wrapped around histones to form chromatin thread, which further condenses to form chromosomes.
  8. Histones provide a structural framework to chromosomes and make them more compact to fit inside the nucleus.
  9. Histone octamers are a complex of eight positively charged histone proteins that assist in DNA packaging.
  10. These are seen at the center of the nucleosome core particle. Histones comprise two copies of each of the 4 core histone proteins – H2A, H2B, H3, and H4.
  11. This octamer gathers when a tetramer consisting of two copies of H3 and H4 composites with 2 dimers of H2A/H2B.

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