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Question

How does the fluid mosaic model propose the arrangement of proteins?


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Solution

Fluid Mosaic Model:

  1. S.J. Singer and Garth L. Nicolson proposed the fluid mosaic concept of cell membrane for the first time in 1972.
  2. The mosaic model of membrane structure depicts the plasma membrane's structure as a mosaic of components, including phospholipids, proteins, carbohydrates, cholesterol, and proteins, which gives the membrane a fluid nature.
  3. Plasma membranes have a thickness of 5 to 10 nanometers. Various cell types have different quantities of proteins, lipids, and carbohydrates in their plasma membranes.

Arrangement of protein in membrane according to fluid mosaic model:

  1. Proteins are the mosaic's second most important component.
  2. Proteins have a specific affinity for lipid bilayers. Some proteins, such as integrins that function as transmembrane receptors and transport proteins that shuttle molecules across membranes, are completely integrated into the membrane.
  3. Integral proteins are proteins that are fully integrated.
  4. Other proteins, such as estrogen receptors, can only be found on the cell surface or in the cytosol, and are referred to as peripheral proteins.
  5. Some of the globular proteins that are scattered throughout the membrane cross it and protrude on both sides. Transmembrane proteins are what they're termed.
  6. Some items may be able to pass via a channel formed by transmembranal proteins.

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