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Question

Sickle cell anemia is :

A
Characterized by elongated sickle like RBCs with a nucleus
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B
An autosomal linked dominant trait
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C
Caused substitute of valine by glutamic acid in the beta globin chain of hemoglobin
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D
Caused by a change in a single base pair of DNA
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Solution

The correct option is D Caused by a change in a single base pair of DNA
Sickle cell anemia results in an abnormality in the oxygen-carrying protein hemoglobin found in red blood cells.
This leads to a rigid, sickle-like shape of the enucleated RBC's.
It is an autosomal recessive disorder which is caused by a change in a single base pair of hemoglobin gene resulting in glutamic acid (E/Glu) being substituted by valine (V/Val) of the beta globin chain of hemoglobin.

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