Polygenic Disorders & Mitochondrial Disorders

Q. _____ disorders are inherited from the mother only.

1. Monogenic
2. Chromosomal
3. Polygenic
4. Mitochondrial

Q.

Is albinism a polygenic disorder?

Q. Statement 1: Polygenic disorders arise due to mutation in multiple genes.

Statement 2: Sickle-cell anaemia is a polygenic disorder.

1. Only statement 1 is true
2. Only statement 2 is true
3. Both the statements are true
4. Both the statements are false

Q.

Is the sickle cell allele dominant or recessive?

Q. A man is heterozygous for albinism and sickle cell anaemia what proportion of his gamete will contain both disease

Q.

Which of the following is not a polygenic disorder?

1. Diabetes
2. Asthma
3. Cleft lip
4. Klinefelter’s syndrome

Q. Disorders arising due to mutation in multiple genes are called _____ mutation.

1. chromosomal
2. mitochondrial
3. monogenic
4. polygenic

Q. Choose the options associated with Leber hereditary optic neuropathy.

1. Arises due to defect in the nuclear DNA
2. Arises due to defect in mitochondrial DNA
3. Is inherited from both father and mother
4. (a) and (c) above.

Q. Choose the options associated with Leber hereditary optic neuropathy.

1. Is inherited from both father and mother
2. (a) and (c) above.
3. Arises due to defect in the nuclear DNA
4. Arises due to defect in mitochondrial DNA

Q. In humans a hereditary disorder called xeroderma pigmentosum (XP) can result in the inability to repair ultravoilet damage to DNA. Which of the following molecular lesions is most likely to accrue in individual to XP

1. thymine dimers
2. deamination of cytosine
3. depurination
4. single strand DNA breaks
5. double strand DNA breaks

Q. If father had a mutation in his mitochondria and mother was normal. Then in the next generation this mutation will be seen in:

1. All the offsprings
2. One-third of the offsprings
3. 50% of the offsprings
4. None of the offsprings

Q. People suffering from albanism cannot synthesize

1. Suberin
2. Keratin
3. Melanin
4. Collagen

Q. Trisomy (2n + 1) causes retardation in child, which is known as

1. Philadelphina
2. Down's Syndrome
3. Albinism
4. None of these