Advantage of Gene Therapy over Drugs

Q.

What is an application of genetics?

Q. Gene used to treat emphysema is

1. Alpha- 1- antitrypsin
2. Trypsin 1
3. Alpha 1
4. Beta-1- antitrypsin

Q. Explain enzyme-replacement therapy to treat adenosine deaminase deficiency. Mention two disadvantages of this procedure. [3]

Q. Define gene therapy.

Q.

What is the use of recombination?

Q. Which among the following is not a prospect/implication of human genome project?

1. None of these.
2. It is compared to the discovery of antibiotics.
3. It is working to determine genes that can change normal cells to cancerous cells.
4. It holds the prospects of a vast database of knowledge about our genetic identity.

Q. Illustrate any three genes which can be used in gene therapy.

Q. Why do children cured by enzyme-replacement therapy for adenosine deaminase deficiency need periodic treatment? [1]

Q. How ADA deficiency is cured by gene therapy?

Q.

Which of the following is commonly used as a vector before introducing a DNA fragment in human lymphocytes?

1. Retrovirus

2. lambda phage

3. Ti plasmid

4. pBr 322

Q. Gene encoding hirudin is synthesized to

1. Prevent blood clotting
2. to prevent high blood pressure
3. to increase sugar level in blood
4. to decrease stress

Q. The genetic defect adenosine deaminase (ADA) deficiency may be cured permanently by ___________.

1. Introducing bone marrow cells producing (ADA) into cells at an early embryonic stage.
2. Periodic infusion of genetically engineered lymphocytes having functional ADA cDNA.
3. Administrating adenosine deaminase activators.
4. Enzyme replacement therapy.

Q. The first clinical gene therapy was done for the treatment of __________.

1. AIDS
2. Cancer
3. Cystic fibrosis
4. SCID (Serve Combined Immuno Deficiency resulting form deficiency of ADA)

Q.

What part does the environment play in DNA expression?

Q. Study the following steps which are followed during the process of gene therapy while treating a patient of SCID
(i) Retrovirus infects lymphocytes extracted from bone marrow of the patient and cultured.
(ii) Engineered cells are injected into patient's bone marrow.
(iii) Normal allele is inserted into a retrovirus.
(iv) Retrovirus makes a DNA copy of its RNA. This DNA carrying the normal allele gets inserted into the chromosome of the host cell.
Arrange the above given steps in correct sequence and select the correct answer.

1. (iii), (i), (ii) (iv)
2. (iii), (i), (iv), (ii)
3. (iv), (ii), (iii), (i)
4. (iv), (iii), (i), (ii)

Q.

• What is the reason for the difference in the softness in apple and pyrus (naashpati) fruits?

Q. You have studied pharmacogenomics and work in a hospital where a highly potent yet experimental drug is being tested on cancer patients. After a few weeks, only a few patients seem to have their tumors shrunken in size. What would be your next course of action?

1. Try a higher dosage of drug
2. Try a different drug altogether
3. Understand the genetic disposition of the patients who had positive result
4. Help create a new drug that works with varying genetic disposition

Q. Identify the wrong statements :

1. a, b, d
2. a, b, c
3. b, c, d
4. a, c, d

Q. Name the two types of gene therapy.

Q. Which is most common chromosomal aberration seen in cancer-

1. Deletion
2. Invention
3. Duplication
4. Translocation

Q. Which kind of therapy was given in 1990 to a four year old girl with adenosine deaminase deficiency?

1. Radiation therapy
2. Gene therapy
3. Chemotherapy
4. Immunotherapy

Q. Which kind of therapy was given in $1990$ to a four-year-old girl with Adenosine Deaminase(ADA) deficiency?

1. Gene therapy
2. Chemotherapy
3. Immunotherapy
4. Radiation therapy

Q. A patient's genetic information can help in making effective drugs for combating diseases.

1. False
2. True

Q.

what is gilbert syndrome?

Q. What might be an advantage of beginning gene therapy prior to birth?

1. The cells being extremely young. are more receptive of gene therapy.
2. This would give the body plenty of time to utilize the new genes.
3. The body would not reject it as it has not yet recognized 'self'.
4. There probably is not any advantage.

Q. Which vector is used to replace defective gene in gene therapy?

1. Ri plasmid
2. Cosmid
3. Ti plasmid
4. Adenovirus

Q. Read the following statements and choose the correct statements.

1. (i) and (ii)
2. (ii) and (iii)
3. (i), (ii) and (iii)
4. All of these

Q. Cystic fibrosis can be treated by .......... gene therapy.

1. TGP-B
2. TPA
3. DNase
4. BGH

Q. Enzyme adenosine deaminase is deficient in .......... genetic disorder.

1. Muscular dystrophy
2. SCID
3. Colour blindness
4. Alzheimers disease

Q. An example of gene therapy is

1. Production of injectible hepatitis B vaccine
2. Production of test tube babies by artificial insemination and implantation of fertilised eggs.
3. Production of vaccines in food crops like potatoes which can be eaten.
4. Introduction of gene for adenosine deaminase in persons suffering from SCID