Bacterial Synthesis of Insulin (Rat)

Q.

Sex hormones will work without the help of

1. Insulin

2. Gonadotropins

3. Placenta

4. Pituitary

Q.

Who among the following was awarded the Nobel prize for determining the structure of insulin?

1. Fischer

2. Koshland

3. Sanger

4. Watson

Q. In the early experiments conducted by Walter Gilbert and Lydia Villa-Komaroff from Harvard University, the initial product obtained was not insulin but __________.

1. Proinsulin
2. Penicillinase-proinsulin mixture
3. Pre-proinsulin
4. Preinsulin

Q. What were the challenges faced by scientists in producing biologically functional rat insulin?
i. Active insulin has two peptide chains A and B
ii. Natural insulin is secreted in the form of long chain proinsulin which has an additional C peptide
iii. The sequence of rat insulin was not known to scientists
iv. Bacteria could not produce active insulin as the insulin gene was inserted in the penicillinase gene

1. i, ii and iv
2. ii, iii and iv
3. i, iii and iv
4. iv and i

Q. What were the challenges faced by scientists in producing biologically functional rat insulin?
i. Active insulin has two peptide chains A and B
ii. Natural insulin is secreted in the form of long chain proinsulin which has additional C peptide
iii. Sequence of rat insulin was not known to scientists
iv. Bacteria could not produce active insulin as gene was inserted in penicillinase gene

1. i, ii and iv
2. ii, iii and iv
3. i, iii and iv
4. iv and i

Q. How did Eli Lilly synthesis the human insulin ? Mention one difference between
this insulin and the one produced by the human pancreas.

Q. What were the challenges faced by scientists in producing biologically functional rat insulin?
i. Active insulin has two peptide chains A and B
ii. Natural insulin is secreted in the form of long chain proinsulin which has an additional C peptide
iii. The sequence of rat insulin was not known to scientists
iv. Bacteria could not produce active insulin as the insulin gene was inserted in the penicillinase gene

1. i, ii and iv
2. ii, iii and iv
3. i, iii and iv
4. iv and i

Q. What were the challenges faced by scientists in producing biologically functional rat insulin?
i. Active insulin has two peptide chains A and B
ii. Natural insulin is secreted in the form of long chain proinsulin which has an additional C peptide
iii. The sequence of rat insulin was not known to scientists
iv. Bacteria could not produce active insulin as the insulin gene was inserted in the penicillinase gene

1. i, ii and iv
2. ii, iii and iv
3. i, iii and iv
4. iv and i

Q. In the early experiments conducted by Walter Gilbert and Lydia Villa-Komaroff from Harvard University, the initial product obtained was not insulin but __________.

1. Proinsulin
2. Preinsulin
3. A Penicillinase-proinsulin mixture
4. Pre-proinsulin

Q. In the early experiments conducted by Walter Gilbert and Lydia Villa-Komaroff from Harvard University, the initial product obtained was not insulin but __________.

1. Proinsulin
2. Preinsulin
3. A Penicillinase-proinsulin mixture
4. Pre-proinsulin

Q. In the early experiments conducted by Walter Gilbert and Lydia Villa-Komaroff from Harvard University, the initial product obtained was not insulin but __________.

1. Proinsulin
2. Preinsulin
3. Pre-proinsulin
4. Penicillinase-proinsulin mixture