Complex I

Q.

What is the main difference between complex 1 and complex 2?

Q. Which one of the following is an incorrect statement for mitochondrial ETC and oxidative phosphorylation?

1. Enzyme complex I accepts electrons and $H^{+}$ from $NADH$ and $FAD{H}_2$
2. Passage of protons through the channel is coupled to the catalytic site of the $F_1$ for $ATP$ production
3. Cytochrome-c is a mobile protein attached to outer surface of inner mitochondrial membrane
4. $6H+$ passes through $F_0$ from intermembrane space to the matrix down the electrochemical proton gradient to produce $3ATP$

Q.

How are the TCA and ETC related?

Q. The following (P through U) are the main steps of chemosynthetic ATP synthesis in the light reaction. Which answer places them in correct order?

P. H+ concentration gradient established

Q. H+ diffuses through ATP synthase

R. Carriers use energy from electrons to move H+ across the membrane

S. Electrons from PSII pass along electron transport chain

T. Light excites in PSII

U. Energy of H+ flow is used by ATP synthase

1. $PQTSRU$
2. $STPQRU$
3. $TSRPQU$
4. $TSRUQP$

Q. The first ATP is formed in the electron transport chain when hydrogen passes from

1. FMN to FAD
   
2. FMN to CoQ
3. NAD to FMN
4. NAD to CoQ
   

Q. FMN is component of

1. complex III
2. complex IV
3. complex I
4. complex II

Q. Which of the following statements about the electron transport chain is NOT correct

1. It is located in the inner mitochondrion membrane
2. Cytochrome c accepts electrons from complex I
3. Cytochrome oxidase (complex IV) accepts electrons from Cytochrome c
4. Coenzyme Q accepts electrons from complex I and complex II

Q.

What is the primary role of TCA in ATP production?

Q. What is the role of NAD+ in cellular respiration

Q. How many ATPs are formed through oxidative phosphprylation for one molecule of $\alpha$-ketoglutaric acid entering Krebs cycle?

1. 9
2. 8
3. 12
4. 6

Q. ${NADP}^{+}$ is reduced to $NADPH$ in

1. HMP
2. Calvin cycle
3. Glycolysis
4. EMP

Q. Which of the following statements about the electron transport chain is NOT correct

1. It is located in the inner mitochondrion membrane
2. Cytochrome c accepts electrons from complex I
3. Cytochrome oxidase (complex IV) accepts electrons from Cytochrome c
4. Coenzyme Q accepts electrons from complex I and complex II

Q. Which one of the following is an incorrect statement for mitochondrial ETC and oxidative phosphorylation?

1. Enzyme complex I accepts electrons and $H^{+}$ from $NADH$ and $FAD{H}_2$
2. Passage of protons through the channel is coupled to the catalytic site of the $F_1$ for $ATP$ production
3. Cytochrome-c is a mobile protein attached to outer surface of inner mitochondrial membrane
4. $6H+$ passes through $F_0$ from intermembrane space to the matrix down the electrochemical proton gradient to produce $3ATP$

Q. Flavo-proteins are important components of which complex in the ETC of Mitochondria

1. Complex-I
2. Complex-II
3. Complex-IV
4. Complex-III

Q. What is the role of ${\text{NAD}}^{+}$ in cellular respiration?

1. It functions as an electron carrier
2. It is the final electron acceptor for anaerobic respiration
3. It functions as an enzyme
4. It is a nucleotide source for ATP synthesis

Q.

What is considered part of the electron transport system?

Q. Electrons from excited chlorophyll molecule of photosystem II are accepted first by

1. Pheophytin
2. Cytochrome b
3. Cytochrome f
4. Ferredoxin

Q. Which component of ETC transfers four protons?

1. Complex I
2. Complex II
3. Complex IV
4. Complex III

Q. How many ATP equivalents are produced by the oxidation of succinate into fumarate?

1. 2 ATP
2. 3 ATP
3. 1 ATP
4. 4 ATP

Q. Which among the following is an inhibitor of complex I of ETC?

1. Carboxin
2. Carbon monoxide
3. Rotenone
4. Antimycin A

Q. Assertion :Respiratory enzyme found attached to inner mitochondrial membrane is malate dehydrogenase. Reason: It allows acetyl CoA to enter Kerb cycle.

1. Both Assertion and Reason are correct and Reason is the correct explanation for Assertion
2. Both Assertion and Reason are correct but Reason is not the correct explanation for Assertion
3. Assertion is correct but Reason is incorrect
4. Both Assertion and Reason are incorrect

Q. Flavo-proteins are important components of which complex in the ETC of Mitochondria

1. Complex-I
2. Complex-II
3. Complex-III
4. Complex-IV

Q. Assertion :Cytochrome oxidase enzyme contains copper. Reason: Cyanide combines with the copper of cytochrome oxidase and prevents $O_2$ combining with it.

1. Both Assertion and Reason are correct and Reason is the correct explanation for Assertion.
2. Both Assertion and Reason are correct but Reason is not the correct explanation for Assertion.
3. Assertion is correct but Reason is incorrect.
4. Both Assertion and Reason are incorrect.

Q. Cytoplasmic NADH is oxidatively phosphorylated inside mitochondrion. Mitochondrion is impermeable to NADH. Entry into mitochondrion is effected through

1. Facilitated diffusion
2. Active absorption
3. $F_0$ tunnel of elementary particles
4. Shuttle system

Q. In electron transport chain, energy for synthesis is produced when electrons pass between

1. NADH ($H^{+}$) --> FAD
2. Cyt b --> Cyt c
3. Cyt a --> Cyt $a_3$
4. All the above

Q. What is the role of NA$D^{}$⁺ in cellular respiration?

1. It is a nucleotide source for ATP synthesis
2. It functions as a electron carrier
3. It functions as an enzyme
4. It is the final electron acceptor for anaerobic respiration

Q. Cytosol plays an important role in

1. Digestion
2. Reproduction
3. None of the above
4. Breakdown of large molecules

Q. Which component of ETC transfers four protons?

1. Complex I
2. Complex II
3. Complex III
4. Complex IV

Q. $ATP$ synthesis by phosphorylation without use of light related with

1. Chloroplast
2. Mitochondria
3. Z-scheme
4. Cyclic photophosphorylation

Q. Value Based Questions :
What chemical substances would be exchanged between the cytoplasm and the mitochondria? Indicate whether they are entering or leaving the mitochondria.