Study of Disease

Q. Assertion: TMV is a virus which causes mosaic disease.

Reason: TMV has RNA as genetic material.

1. If both assertion and reason are true and reason is the correct explanation of assertion
2. If assertion is true but reason is false
3. If both assertion and reason are true but reason is not the correct explanation of assertion
4. If both assertion and reason are false

Q. For which of these diseases do transgenic mouse models not exist?

1. Cancer
2. Alzheimer’s disease
3. Cystic fibrosis
4. Tuberculosis

Q. Which of the following transgenic organisms is used for the safety testing of Poliovirus?

1. Cattle
2. Monkey
3. Mice
4. Pigs

Q. Which of the following transgenic organisms is used for the safety testing of Poliovirus?

1. Cattle
2. Pigs
3. Mice
4. Monkey

Q. Match the following columns and select the correct option.
$\begin{array}{cccc}& \text{Column I}& & \text{Column II}\\ \left(a\right)& \text{Bt cotton}& \left(i\right)& \text{Gene therapy}\\ \left(b\right)& \text{Adenosine}& \left(ii\right)& \text{Cellular defence}\\ & \text{deaminase deficiency}& & \\ \left(c\right)& \text{RNAi}& \left(iii\right)& \text{Detection of HIV infection}\\ \left(d\right)& \text{PCR}& \left(iv\right)& \text{Bacillus thuringiensis}\end{array}$

1. (a) -(ii), (b)-(iii), (c)-(iv), (d)-(i)
2. (a)-(i), (b)-(ii), (c)-(iii), (d)-(iv)
3. (a)-(iv), (b)-(i), (c)-(ii), (d)-(iii)
4. (a)-(iii), (b)-(ii), (c)-(i), (d)-(iv)

Q. Sometimes a gene which carries a major disadvantage in homozygous state confers an advantage in the heterozygous condition. Explain by giving a suitable example.

1. Down's syndrome
2. Cystic fibrosis
3. Sickle cell anemia
4. None of the above

Q.

what is a sterile organism?

Q. It is said, that the harmful alleles get eliminated from the population over a period of time, yet sickle cell anaemia is persisting in human population. Why?

Q. For which of these diseases do transgenic mouse models not exist?

1. Cancer
2. Cystic fibrosis
3. Alzheimer’s disease
4. Tuberculosis

Q. With respect to understanding diseases, discuss the importance of transgenic animal models.