Type I and II Diabetes

Q. Some of the steps involved in the production of Humulin are given below. Choose the correct statements regarding it.

i) Synthesis of gene (segment of DNA) for human insulin artificially and insertion of the gene into retroviral vectors.
ii) Introduction of recombinant plasmid into Escherichia coli and culturing recombinant cells in bioreactors.
iii) Extraction of recombinant gene product from Escherichia coli.
iv) Purification of humulin.

1. i, ii, iii, iv
2. ii, iii, iv
3. i, ii, iv
4. i, ii, iii

Q. Match column I with column II and select the correct option from the given codes.

	Column-I		Column-II
A.	GLUT-4	(i)	Intercellular ground substance
B.	Antibody	(ii)	Enzyme
C.	Collagen	(iii)	Hormone
D.	Trypsin	(iv)	Fights infectious agents
E.	Insulin	(v)	Enables glucose transport in cells

1. A-(i), B-(ii), C-(iii), D-(iv), E-(v)
2. A-(v), B-(iv), C-(i), D-(ii), E-(iii)
3. A-(v), B-(iv), C-(iii), D(ii), E-(i)
4. A-(ii), B-(i), C-(iv), D(v), E-(iii)

Q. Select the correct set of the names for A, B, C and D :-

	A	B	C	D
(A)	Proinsulin	B-Peptide	A-Peptide	Insulin
(B)	Proinsulin	A-Peptide	B-Peptide	Free C-Peptide
(C)	Proinsulin	A-Peptide	B-Peptide	Insulin
(D)	Proinsulin	B-Peptide	A-Peptide	Free C-Peptide

1. D
2. C
3. A
4. B

Q. Some of the steps involved in production of Humulin are given below. Choose the correct sequence.

(i) Synthesis of insulin gene artificially
(ii) Culturing recombinant E. coli in bioreactors
(iii) Purification of Humulin
(iv) Insertion of human insulin gene into plasmid
(v) Introduction of recombinant plasmid into E. coli
(vi) Extraction of recombinant gene product from E. coli

1. (i), (v), (vi), (ii), (iv), (iii)
2. (i), (iv), (v), (ii), (vi), (iii)
3. (iv), (iii), (v), (ii), (vi), (i)
4. (i), (ii), (vi), (iii), (v), (iv)

Q. Choose the correct option and complete the sentence:
(b) Insulin is secreted by _____ cells of pancreas

1. delta
2. alpha
3. beta

Q. ___(i)____ regulates blood sugar levels and is secreted from beta-cells of ___(ii)____.

1. (i)Glucagon, (ii)pancreas
2. (i)Insulin, (ii)pancreas
3. (i)Insulin, (ii)liver
4. (i)Glucagon, (ii)liver

Q. Name the endocrine gland which secretes growth hormone. What will be its effect on person of excess secretion of growth hormone.

Q. Select the correct set from the alternatives given below.

1. $\begin{array}{cccc}& \text{Trypsin}& -& \text{Hormone}\end{array}$
2. $\begin{array}{cccc}& \text{Insulin}& -& \text{Enzyme}\end{array}$
3. $\begin{array}{cccc}\text{(C)}& \text{GLUT-4}& -& \text{Enables glucose}\\ & & & \text{transport into cells}\end{array}$
4. $\begin{array}{cccc}\text{(D)}& \text{Collagen}& -& \text{Intracellular ground}\\ & & & \text{substance}\end{array}$

Q. Which of the following statement is correct?

1. Glucagon and insulin are secreted by different cells and have opposite effect.
2. Glucagon and insulin are secreted by different organs.
3. None of the above
4. Glucagon and insulin are secreted by same cells.

Q. Which cells in the 'Islets of Langerhans' secrete insulin?

1. α
2. β
3. δ
4. PP

Q. ___(i)____ regulates blood sugar levels and is secreted from beta-cells of ___(ii)____.

1. (i)Glucagon, (ii)pancreas
2. (i)Insulin, (ii)pancreas
3. (i)Insulin, (ii)liver
4. (i)Glucagon, (ii)liver

Q. ___(i)____ regulates blood sugar levels and is secreted from beta-cells of ___(ii)____.

1. (i)Insulin, (ii)liver
2. (i)Glucagon, (ii)liver
3. (i)Glucagon, (ii)pancreas
4. (i)Insulin, (ii)pancreas

Q. Which cells in the 'Islets of Langerhans' secrete insulin?

1. α
2. β
3. δ
4. PP

Q. Which pair of chromosomes contains the insulin controlling gene in humans.

Q. In all of the following first term is a building block of the second term except

1. Amino acid - Haemoglobin
2. Nitrogen - Uric acid
3. Thymine - Nucleotide
4. Glucose - Chitin
5. Fatty acid - Insulin