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Question

A competitive inhibitor of succinate dehydrogenase is:

A
α -ketoglutarte
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B
Malate
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C
Malonate
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D
Oxaloacetate
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Solution

The correct option is C Malonate
Malonate is a powerful inhibitor of cellular respiration because it binds to the active site of the succinate dehydrogenase in the citric acid cycle, thereby competes with succinate which is its natural substrate.

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