Question

A competitive inhibitor of succinic dehydrogenase is

• A. $\alpha$-ketoglutarate
• B. Malate
• C. Malonate
• D. Oxaloacetate

Answer 1

The correct option is C Malonate

A competitive inhibitor is one that competes with the substrate molecules for the active site of the enzyme. Competitive inhibitor resembles the natural substrate and combines reversibly with the free enzyme at the active site. This results in the competition between the substrate and inhibitor for the active site of the enzyme. Malonate inhibits succinate dehydrogenase activity. The structure of malonate is similar to succinate. This is an example of competitive inhibition.

Thus, the correct answer is option C.