A Fischer projection of (2R, 3S)-2,3-butanediol is:
A
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B
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C
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D
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Solution
The correct option is A Cases of R and S nomenclature
If the 4th (least) priority group is on the vertical position then clockwise direction from priority order 1 to 3 will be R.
If the 4th (least) priority group is on the vertical position then anti-clockwise direction from priority order 1 to 3 will be S.
If the 4th (least) priority group is on the horizontal position then clockwise direction from priority order 3 to 1 will be R.
If the 4th (least) priority group is on the horizontal position then anti-clockwise direction from priority order 3 to 1 will be S.
The R/S nomenclature of all the four given structure is given by
Hence correct fischer projection of (2R, 3S)-2,3-butanediol is option a. ⇒ The compound is optically inactive even though it has 2 chiral carbons because of 2R and 3S.