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Question

A patient comes with symptoms of hemolysis. The diagnostic tests reveal that he has auto-antibodies to red blood cells (RBCs). Which one of the following mechanisms is the cause of this condition?

A
Neutrophils release granzymes which lyse RBCs
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B
Complement is activated and membrane attack complex lyse RBCs
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C
Cytotoxic T-cells lyse RBCs
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D
Interleukin-2 binds to the receptor on RBCs
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Solution

The correct option is D Cytotoxic T-cells lyse RBCs
Autoimmune hemolytic anaemia (AIHA) occurs when antibodies directed against the person's own red blood cells (RBCs) cause them to burst (lyse), leading to an insufficient number of oxygen-carrying red blood cells in the circulation. Cytotoxic T-cells lyses of RBCs is the mechanism the cause of this condition.
So, the correct answer is 'Cytotoxic T-cells lyse RBCs'

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