The correct option is B Antibodies
The encounter of B cell with a specific antigen activates its clonal expansion which in turn gives rise to plasma cell and memory cells. Memory cells are the B cells (antibodies) responsible for long-term immunity and confirm the previous encounter of a person with the specific virus. Antigens are foreign substances that induce the immune system to produce antibodies. Disease-causing organisms are called as pathogens. Natural killer cells and macrophages are components of immune system. So, the correct answer is option D.