Question

A person with $44A+XXY$ chromosome set up has gynecomastia and is Barr body positive. They are symptoms of

• A. Turner's syndrome
• B. Klinefelter's syndrome
• C. Down's syndrome
• D. Edward's syndrome

Answer 1

The correct option is B Klinefelter's syndrome

Klinefelter’s Syndrome is an aneuploid condition marked by the presence of one or more extra chromosomes in a male (44+XXY/ 44+XXXY/ 44+XXXXY). As we know that, to compensate the dosage of X-linked genes in human male and female, one X-chromosome in females is deactivated and is present as darkly stained body near nuclear envelope. The number of Barr bodies is always one less than the total number of X chromosomes. A human male with Klinefelter’s syndrome, 44+XXY/ 44+XXXY/ 44+XXXXY, can have 1, 2 or 3 Barr bodies, depending on the number of X-chromosome. The presence of extra copy of X-chromosome produces some feminine characters in otherwise male individuals. They are sterile feminised males with enlarged breasts (Gynecomastia).

So, the correct answer is 'Klinefelter's syndrome'.