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Question

ADA deficiency results in

A
Increased risk of infertility
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B
Inability of immune system to function normally
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C
Chromosomal disorders
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D
Decrease in yield of crop plants
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Solution

The correct option is B Inability of immune system to function normally
  • Adenosine deaminase deficiency is an autosomal recessive metabolic disorder that causes immunodeficiency.
  • ADA deficiency may be present in infancy, childhood, adolescence, or adulthood.
  • ADA deficiency is due to a lack of the enzyme adenosine deaminase. This deficiency results in an accumulation of deoxyadenosine in which T cells undergo proliferation and development in the thymus, affected individuals typically have a small, underdeveloped thymus.
  • As a result, the immune system is severely compromised or completely lacking. Hence, ADA deficiency results in the Inability of the immune system to function normally.
So, the correct answer is 'Inability of the immune system to function normally'.

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