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Question

After removal of signal peptide, the secretory protein involved in formation of insulin is known as

A
Preinsulin
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B
Proinsulin
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C
Postinsulin
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D
Prepinsulin
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Solution

The correct option is B Proinsulin
The insulin mRNA is translated as a single chain precursor called preproinsulin, and removal of its signal peptide during insertion into the endoplasmic reticulum generates proinsulin. Insulin and free C peptide are packaged in the Golgi into secretory granules which accumulate in the cytoplasm.
So, the correct answer is 'Proinsulin.'

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