The correct option is
B Non- infectious and increased secretions of IgE
An allergen is a usually harmless substance capable of triggering a response that starts in the immune system and results in an allergic reaction.
IgE is an immunoglobulin that plays a central role in acute allergic reactions and chronic inflammatory allergic diseases.
Human allergy is caused by a limited number of inhaled small-protein allergens that reproducibly elicit IgE production in susceptible individuals.
So the answer is option B ' Non- infectious and increased secretions of IgE'.