Question

Allosteric modulation is due to the inhibition action of enzyme by

• A. Competitive inhibition
• B. Substrate concentration
• C. Products of reaction
• D. Enzyme concentration
• E. Non competitive inhibition

Answer 1

Answer: (C)

Products of reaction

Allosteric modulation is also called feed back inhibition. It is an enzyme regulatory mechanism where a product of a simple or chain reaction can function as temporary allosteric inhibitor. An allosteric inhibitor combines with a regulator or allosteric site, other than active site if its concentration crosses a threshold value. For example, excess of glucose-6-phosphate stops the activity of enzyme hexokinase that helps in its formation from glucose and ATP.