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Anaphase

Anaphase Prom...

Question

Anaphase Promoting Complex (APC) is a protein degradation machinery necessary for proper mitosis of animal cells. If APC is defective in a human cell, which of the following is expected to occur ?

A

Chromosomes will not condense

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B

Chromosomes will be fragmented

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C

Chromosomes will not segregate

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D

Recombination of chromosome arms will occur

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Solution

The correct option is C Chromosomes will not segregate
In mitosis, anaphase stage is characterised by the centromeres splitting, chromatids separation and movement of chromatids to opposite poles. If Anaphase Promoting Complex (APC) is defective, chromosomes will not be able to segregate which is necessary for separation of chromosomes in anaphase stage.

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