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B
at constant regions
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C
only if macrophages are present
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D
both (a) and (C)
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Solution
The correct option is A at variable regions In the blood, the antigens are specifically and with high affinity bound by antibodies to form an antigen-antibody complex. The antigenic determinant or epitope is recognized by the paratope of an antibody, situated at the variable region of the polypeptide chain.