Assertion :Azathioprine is given just before and after transplantation Reason: It inhibits mitosis and leads to immunosuppression.

Both Assertion and Reason are correct and Reason is the correct explanation for Assertion

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Both Assertion and Reason are correct but Reason is not the correct explanation for Assertion

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Assertion is correct but Reason is incorrect

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Both Assertion and Reason are incorrect

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Solution

The correct option is A Both Assertion and Reason are correct and Reason is the correct explanation for Assertion
Azathioprine is an immunosuppressant that suppresses the immune, or defence, system. It is given before and after transplantaion as it is usually started together with steroids to allow tapering of steroids to the lowest dose possible and following organ transplant operations, it is natural for the body to try to reject the new tissue as it regards it as foreign. Thus, by suppressing the defence system, it helps to prevent the body from fighting the new organ. It acts predominantly on the G1 and S phases of the cell cycle.
So, the correct answer is option A.

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