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Question

Assertion :

Hormones interacting with cell surface receptors do not enter the target but they generate second messenger.

Reason:

Glucocorticoids bind to intracellular receptors and regulate gene expression.


A
Both Assertion and Reason are correct and Reason is the correct explanation for Assertion
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B
Both Assertion and Reason are correct but Reason is not the correct explanation for Assertion
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C
Assertion is correct but Reason is incorrect
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D
Both Assertion and Reason are incorrect
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Solution

The correct option is B Both Assertion and Reason are correct but Reason is not the correct explanation for Assertion
The hormones which interact with cell surface receptors are peptide hormones. They do not enter the target cells but generate a second messenger such as cAMP (cyclic adenosine monophosphate) which delivers information inside the target cells. Hence assertion is true.
Glucocorticoids are steroid hormones which can cross the lipid bilayer and enter the target cell where they bind to receptors and induce transcription of genes. Thus, steroid hormones act by regulating gene expression. Hence reason is also true but is not correct explanation for assertion.
So, the correct answer is 'Both A and R are true but R is not correct explanation of A'.

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