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Question

Binding of specific proteins on regulatory DNA sequences can be studied by means of

A
Electron microscope
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B
Light microscope
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C
Centrifugation
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D
X-ray crystallography
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Solution

The correct option is D X-ray crystallography
X-ray crystallography is a technique to study the structural details of crystallizable proteins and nucleic acids. X-ray microscope developed by Kirkpatrick is useful in studying detailed structures of chemicals present in solid state, e.g., haemoglobin, insulin, DNA, RNA etc. due to diffraction of X rays by different atoms of the substance.
Binding of specific proteins on regulatory sequences of DNA will generate specific diffraction pattern of X rays which can help to identify specific proteins binding to specific regulatory regions in DNA.

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