Deep wounds cause loss of blood. To prevent that, tissues degenerate to form the enzyme known as thromboplastin. Thromboplastin converts prothrombin in the plasma to thrombin. Vitamin K and Calcium ions are essential for the synthesis of prothrombin. Thrombin further converts the fibrinogen in the plasma to fibrin. Then, a blood clot is formed by the entangling of platelets and red blood cells in the fibrin network.