Question

Chloramphenicol prevents protein synthesis over

• A. Prokaryotic ribosomes
• B. Organelle ribosomes
• C. Both A and B
• D. 80 S ribosomes

Answer 1

The correct option is C Both A and B

• Chloramphenicol is an antibiotic (bacteriostatic) which binds to the 50S ribosomal subunit of the prokaryotic cell and cell organelle (70S type).
• It prevents the protein synthesis by inhibiting the peptidyltransferase step.
• It occurs mainly due to inactivation of the antibiotic by chloramphenicol acetyltransferase enzymes.
  
• It prevents the protein synthesis over both the prokaryotic and organelle ribosome.
• So, the correct answer is 'Both A and B'.