Chromosome complement of two sperms and two eggs of human being is shown below. Fusion of which gametes will create a defect in offspring known as Klinefelter's syndrome?
[0.7 mark]

A with B

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D with C

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A with C and D with B

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A with B or C

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Solution

The correct option is C A with C and D with B
Klinefelter’s syndrome develops due to the presence of an additional copy of X-chromosome resulting into 44 + XXY chromosome complement. The defect appears due to fusion of an abnormal egg (22 + XX) with normal sperm (22 + Y) or normal egg (22 + X) with abnormal sperm (22 + XY).

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Similar questions

Q. Why people with klinefelter syndrome sterile?
Since they have x x y chromosomes what type of gametes can be formed ?

Q. Chromosomal abnormalities occur during meiosis, a process that produces gametes (eggs and sperm) within human bodies. Abnormalities occur when there is an uneven split of chromosomes into each gamete. The following table shows 6 of the most common syndromes associated with chromosomal abnormalities.

\begin{matrix} Syndrome name & Chromosome Affected & Incidence per 10,000 births & Type of mutation Polyploidy & Extra complete set of chromosomes & Fatal, doesn't reach full term & Addition Patau syndrome & 13 & 2 & Addition Edwardsn syndrome & 18 & 3 & Addition Down syndrome & 21 & 15 & Addition Klinefelter syndrome & 23 & 10(affects only males)) & Addition Turner Syndrome & 23 & 2(affects only females)) & Deletion \end{matrix}

(I) Following 30,000 of all births, how many children would be predicted to have Turner syndrome?
(a) 0
(b) 3
(c) 4
(d) 6

(II) From above mentioned table, what is the sex chromosome makeup of a child with Klinefelter syndrome?
(a) XO
(b) XY
(c) XXY
(d) XX

(III) The incidence of Down’s syndrome increases with maternal age, and not significantly with paternal age. What may reasonably explain this trend?
(a) Failure of muscular contractions to correctly fuse the two gametes.
(b) Gradual accumulation in germ-line chromosomal mutations throughout reproductive age.
(c) Maternal oocytes have a longer period of meiosis than paternal spermatozoa, and thus, there are more opportunities for mutations to develop.
(d) Maternal mitochondrial DNA is mutated in Down’s syndrome.

Q. What would be the number of chromosomes in the ovum (fertilized by a normal sperm) that resulted in the appearance of Klinefelter's syndrome in the offspring?

Choose the correct option:

Assertion [A]: Patients having Klinefelter syndrome have higher amounts of estrogen in the body.
Reason [R]: Klinefelter syndrome occurs due to appearance of an extra X chromosome in the human males.

Choose the correct option regarding the Assertion and Reason:

Assertion [A]: Patients having Klinefelter syndrome have higher amounts of estrogen in the body.
Reason [R]: Klinefelter syndrome occurs due to appearance of an extra X chromosome in the human males.

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Chromosome complement of two sperms and two eggs of human being is shown below. Fusion of which gametes will create a defect in offspring known as Klinefelter's syndrome? [0.7 mark]

Chromosome complement of two sperms and two eggs of human being is shown below. Fusion of which gametes will create a defect in offspring known as Klinefelter's syndrome?
[0.7 mark]