CO and CN− are harmful.
Cyanide (CN−) inhibits the electron transport chain in the cell, which prevents aerobic respiration.
Carbon monoxide (CO) bonds to hemoglobin more easily than oxygen. it decreases the capacity of blood to carry oxygen, and starves the cells of oxygen. eventually the victim dies of hypoxia (lack of oxygen), the same way they would if they were not breathing.
Hence, option 1 is correct.