Question

Comparing the genetic maps of homologous genes in human and mouse chromosomes, the genes that make up 40% of human chromosome 1 are present

• A. As a single contiguous block in mouse chromosome 1
• B. In mouse chromosome 4
• C. As a single block in mouse chromosome 3
• D. All of the above

Answer 1

The correct option is D All of the above

The linkage groups present at adjacent regions of human chromosome 1 are mapped to discrete regions on distal mouse chromosomes 1 and 3. The gene order within the linkage groups is conserved between human and mouse. The 15 genes present between 1q21 and 1q32 on human chromosome 1 are mapped to 29.5 cM on distal mouse chromosome 1 and 6 genes present between human chromosome 1q21 and 1p22 span 15.6 cM on distal mouse chromosome 3. The human CYP2J gene (CYP2J2) that encodes for cytochromes P450 is present on human chromosome 1 and the corresponding mice gene is present at the central region of chromosome 4 distal to the Jun oncogene. The correct answer is D.