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Question

Degeneration of genetic code is due to

A
First member of codons
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B
Second member of codons
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C
Third member of codons
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D
Entire codons
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Solution

The correct option is C Third member of codons
In genetic code table, each box is specified by the first and second positions (for example the AAX box, in which X is any of the four bases) therefore eight of the sixteen boxes contain just one amino acid per box. This means codon need only be read in the first two positions for these eight amino acids the because the same amino acid will be represented regardless of the third base of the codon. That’s why multiple codons specify single amino acid and make the genetic code degenerate. There is the strong base pairing between first two bases of an mRNA codon and corresponding bases of the tRNA anticodon and first base of the anticodon (5’-3’direction) pairs with the third base of the codon; this makes options A and B wrong. Thus, the codon base of lesser importance is the number-three base, whereas it is the number-one base in the anticodon. The correct answer is C.

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