In multiple fission, the parent cell’s nucleus divides many times by the process of amitosis, that is, direct cell division, giving rise to many nuclei.
Afterward, the cytoplasm separates, giving rise to multiple daughter cells.
The process of multiple fission takes place during unfavorable conditions.
At the cellular level, multiple fission takes place in many protists like amoeba and sporozoans.
For example, in an amoeba, which is a unicellular organism, in unfavorable conditions, the pseudopodia are withdrawn and turn into a round shape.
A hard covering is secreted around its cell known as a cyst.
The nucleus of amoeba, within the cyst, goes through repeated divisions to produce many nuclei.