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Drugs that bind to the receptor sites and inhibit its natural function are called antagonists
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Drugs that bind to the receptor sites and inhibit its natural function are called antagonist. A competitive antagonist is a receptor antagonist that binds to a receptor but does not activate the receptor. The antagonist will compete with available agonist for receptor binding sites on the same receptor. Sufficient antagonist will displace the agonist from the binding sites, resulting in a lower frequency of receptor activation.

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