Question

During chloride, shift or Hamburger phenomenon, when the whole blood is saturated with $C{O}_2$, following changes occurs. Which one of them is not correct?

• A. Bicarbonate content of plasma and corpuscles increase
• B. Chloride content of plasma diminished and that of the cell is increased
• C. Total base of blood remain unchanged
• D. Water content and volume of corpuscles decrease

Answer 1

The correct option is D Water content and volume of corpuscles decrease

According to Hamburger phenomenon, when the whole blood is saturated with carbon dioxide, the following changes are seen.
(i) The bicarbonate contents of plasma and corpuscles increase.
(ii) The chloride content of plasma is diminished and that of the cell is increased.
(iii) The total base(cations) of both plasma and corpuscles remain unchanged.
(iv) The water content and the volume of corpuscles increase.
(v) When the carbon dioxide is removed from the blood reverse changes takes place.
(vi) When $C{O}_2$ enters blood, $C{l}^{-}$ from plasma enters RBC's leaving $N{a}^{+}$ behind. When $C{O}_2$ escapes from blood $C{l}^{-}$ leaves the cell and combines with $N{a}^{+}$ again. Due to the alternate movement of $C{l}^{-}$ ions, this phenomenon is called chloride shift.

So, the correct answer is option D.