During the processing of the prohormone "proinsulin" into the mature "insulin", which of the following occurs?

C peptide is added to proinsulin

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C peptide is removed from proinsulin

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B peptide is added to proinsulin

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B peptide is removed from proinsulin

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Solution

The correct option is B C peptide is removed from proinsulin
Insulin consists of two short polypeptide chains - chain A and chain B, which are linked together by disulfide bridges. In mammals, including humans, insulin is synthesized as a prohormone like a pro-enzyme which contains an extra stretch called the C peptide. This C peptide is not present in the mature insulin and is removed during maturation into insulin.

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The given figure represents the maturation of proinsulin into insulin. Identify the product A.

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