ELISA can give a false test in the beginning of an infection due to

Low antibody

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Denatured pathogen

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Low concentration of pathogen

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Antibody may not bind tightly to the titer plate

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Solution

The correct option is C Low concentration of pathogen
ELISA works on the principle of antibody-antigen interaction. In case of low concentration of pathogen it can give false test in the beginning of infection. A low concentration of pathogen will fail to produce sufficient antibodies that are required to show a positive status for a particular disease or condition thereby making it seem like an individual is negative for a disease even if in reality he/she is in fact positive for it.

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