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Question

FAD+ is reduced during conversion of

A
Citric acid to isocitric acid
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B
Isocitric acid to α ketoglutaric acid
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C
α ketoglutaric acid to succinyl CoA
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D
Succinic acid to fumaric acid
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Solution

The correct option is D Succinic acid to fumaric acid
During one of the steps of Krebs cycle, succinic acid is converted to fumaric acid. The reaction is accompanied by coenzyme FAD (flavin adenine nucleotide). This oxidation reaction liberates less free energy as compared to other oxidation reactions.FAD+ is the hydrogen acceptor in this reaction as there is very less free-energy change. In this reaction, succinic acid is oxidized to fumaric acid. At the same time, FAD+ is reduced to FADH2.
Thus, the correct answer is option D.

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