First oxidative decarboxylation in aerobic respiration occurs during the conversion of

oxalosuccinic acid to isocitric acid

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pyruvic acid to acetyl CoA

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α

-ketoglutaric acid to succinyl CoA

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fumaric acid to malic acid

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Solution

The correct option is B pyruvic acid to acetyl CoA
Each pyruvate molecule, after coming out of glycolysis, gets oxidized and loses a carbon atom in the form of $C O_{2}$ . The remaining carbons are then transferred to coenzyme A (CoA) to produce acetyl CoA. Acetyl CoA then enters the Krebs cycle. The rest of the given reactions are a part of the Krebs cycle.

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C O_{2}

\begin{matrix} I . C i t r i c a c i d & \to & α - k e t o g l u t a r i c a c i d I I . S u c c i n i c a c i d & \to & M a l i c a c i d I I I . M a l i c a c i d & \to & O x a l o a c e t i c a c i d I V . α - k e t o g l u t a r i c a c i d & \to & S u c c i n y l C o - A \end{matrix}

Fate of puruvic acid in aerobic respiration is decarboxylation or oxidation?

α

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