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Question

Following graph represents oxyhemoglobin dissociation curve. Point E and G represent venous O2 pressure during exercise and resting state respectively. How much total percentage of oxygen is unloaded in tissue during exercise?

(correct answer + 2, wrong answer - 0.50)

A
R
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B
Q
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C
P + Q
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D
P + Q + R
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Solution

The correct option is C P + Q
In the tissues, where low pO2, high pCO2, high H+ concentration and higher temperature exist, the conditions are favorable for dissociation of oxygen from the oxyhaemoglobin. This clearly indicates that O2 gets bound to hemoglobin in the lung surface and gets dissociated at the tissues.
So, during exercise, muscles have a higher metabolic rate, and consequently need more oxygen, produce more carbon dioxide and lactic acid, and their temperature rises.
Hence, at point P and Q, curve shifts towards right.

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