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Question

Frederick Griffith accidentally discovered transformation when attempting to
develop a vaccine for pneumonia. He injected mice with samples from S strain
(virulent) and/or R strain (non-virulent) pneumococcal bacteria (Streptococcus
pneumoniae). Which of the following results is NOT consistent with Griffith's
experiments?

A
Injected S strain: Mouse dies
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B
Injected R strain: Mouse lives
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C
Injected heat-killed S strain: Mouse lives
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D
Injected mixture of heat-killed S strain and live R strain: Mouse lives
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Solution

The correct option is D Injected mixture of heat-killed S strain and live R strain: Mouse lives
The result- Injected mixture of heat-killed S strain and live R strain: Mouse lives, is not consistent with Griffith's experiments.

When the mouse was injected with a mixture of heat-killed S strain and live R strain, the mouse died.

Based on this observation, Griffith concluded that some transforming principle (a chemical substance) from the heat-killed, smooth S strain virulent bacteria had entered the living, rough R strain non-virulent bacteria and transformed the latter into virulent bacteria which in turn led to the death of the mouse due to pneumonia infection.

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