Give a plausible explanation for the following.
Cyclohexanone forms cyanohydrins in good yield but $2, 2, 6$ - trimethyl cyclohexanone does not.

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Solution

Cyclohexanones form cyanohydrins according to the following equation shown on the figure i.
Here the nucleophile $C N^{-}$ can easily attack without any steric hindrance.
However, in the case of $2, 2, 6$ trimethylcyclohexanone. $- C H_{3}$ groups at $α$ positions offersteric hindrances and as a result . $C N^{-}$ can not attack effectively. See the figure ii.
$2, 2, 6$ - trimethylcyclohexanone.

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Q. Cyclohexanone forms cyanohydrin in good yield but 2,2,6-trimethytcyclohexanone does not. Explain why ?

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Give a plausible explanation for the following.Cyclohexanone forms cyanohydrins in good yield but 2,2,6 - trimethyl cyclohexanone does not.

Give a plausible explanation for the following.
Cyclohexanone forms cyanohydrins in good yield but $2, 2, 6$ - trimethyl cyclohexanone does not.