Given below are assertion and reason. Point out if both are true with reason being correct explanation (A), both are true but reason is not correct explanation (B), assertion is true but reason is wrong (C) and both are wrong (D).
Assertion. HbSHbS is homozygous condition of sickle cell anaemia.
Reason. It occurs due to substitution of glutamic and by valine at sixth position in β-chain of hemoglobin.
Given below are assertion and reason. Point out if both are true with reason being correct explanation (A), both are true but reason is not correct explanation (B), assertion is true but reason is wrong (C) and both are wrong (D).
Assertion. HbSHbS is homozygous condition of sickle cell anaemia.
Reason. It occurs due to substitution of glutamic and by valine at sixth position in β-chain of hemoglobin.
The correct option is B B
Sickle cell
anaemia is an autosomal disorder. It is
the most common genetical disorder appear in Africans. It is due to the homozygous
condition of the gene HbS HbS. The disease is due to the
substitution of sixth codon in gene coding for the b-chain of Haemoglobin. Due to this,
sixth amino acid in b-chain of Haemoglobin Glutamic acid
is replaced by valine. The main symptom of this disorder is decrease of oxygen
uptake. Both Assertion and Reason are true, reason is not the correct explanation
of A.
So,
the correct option is ‘B’.
Sickle cell anaemia is an autosomal disorder. It is the most common genetical disorder appear in Africans. It is due to the homozygous condition of the gene HbS HbS. The disease is due to the substitution of sixth codon in gene coding for the b-chain of Haemoglobin. Due to this, sixth amino acid in b-chain of Haemoglobin Glutamic acid is replaced by valine. The main symptom of this disorder is decrease of oxygen uptake. Both Assertion and Reason are true, reason is not the correct explanation of A.
So, the correct option is ‘B’.
