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D CO
2The Haldane effect is due to the higher affinity of deoxygenated haemoglobin for CO2 than oxyhaemoglobin as it is a better proton acceptor than oxyhaemoglobin. Therefore, when haemoglobin is deoxygenated (i.e., at tissues) there is a right shift of the carbonic acid-bicarbonate buffer equation to produce H+, which in turn increases the amount of CO2 , which can be carried by the blood back to the lungs to be exhaled. Then, with oxygenation at the lungs CO2 CO2 dissociates more readily from haemoglobin.