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Question

Haldane effect refers to

A
More acidity in the blood
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B
Less acidity in the blood
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C
More basicity in the blood
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D
Less basicity in the blood
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Solution

The correct option is A More acidity in the blood
  • The Haldane effect is due to the higher affinity of deoxygenated haemoglobin for CO2 than oxyhaemoglobin as it is a better proton acceptor than oxyhaemoglobin.
  • Therefore, when haemoglobin is deoxygenated (i.e., at tissues) there is a right shift of the carbonic acid-bicarbonate buffer equation to produce H+ (increase in acidity), which in turn increases the amount of CO2​ , which can be carried by the blood back to the lungs to be exhaled.
  • Then, with oxygenation at the lungs, CO2 dissociates more readily from haemoglobin. Hence, Option A is correct.

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